HDAC6 Rabbit monoclonal antibody
Product Specifications
Background
Involved in the regulation of many cellular processes, including cell migration, immune synapse formation, viral infection, and degradation of misfolded proteins. HDAC6 binds to both poly-ubiquitinated misfolded proteins and dynein motors, facilitating the transport of misfolded proteins to the aggresome. Required for subsequent recruitment of the autophagic machinery and clearance of aggresomes from the cell. Plays a key role in the protection against the deleterious effects of pathological protein aggregation that occurs in various diseases.
CAS Number
9007-83-4
Structure Composition
Rabbit IgG, 1mg/ml in PBS with 0.02% sodium azide, 50% glycerol, pH7.2.
Product Name Alternative
HD 6; HDAC 6; Histone deacetylase 6 (HD6) ; JM 21
Swiss Prot
Q9UBN7
Reactivity
Human
Immunogen
A synthesized peptide derived from human HDAC6
Conjugation
Unconjugated
Applications
WB IHC ICC/IF IP
Dilution
WB 1:5000~1:20000 IHC 1:50~1:200 ICC/IF 1:100~1:500 IP 1:50
Purity
Affinity-chromatography
Modification
Unmodified
Molecular Weight
160kDa
Storage Conditions
Store at 4°C short term. Aliquot and store at -20°C long term. Avoid freeze-thaw cycles.
Notes
For research use only, not for use in diagnostic procedure.
Specificity
HDAC6 Antibody detects endogenous levels of HDAC6
Applications Notes
Western blot analysis of HDAC6 expression in HeLa cell lysate.
Host or Source
Rabbit
Available Sizes
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