Phospho-Tau (T231) Rabbit monoclonal antibody

Product Specifications

Background

Tau is a heterogeneous microtubule-associated protein that promotes and stabilizes microtubule assembly, especially in axons. Six isoforms with different amino-terminal inserts and different numbers of tandem repeats near the carboxy-terminus have been identified, and tau is hyperphosphorylated at approximately 25 sites by ERK, GSK-3 and CDK5. Phosphorylation decreases the ability of tau to bind to microtubules. Neurofibrillary tangles are a major hallmark of Alzheimer's disease and these tangles are bundles of paired helical filaments composed of hyperphosphorylated tau.

CAS Number

9007-83-4

Structure Composition

Rabbit IgG, 1mg/ml in PBS with 0.02% sodium azide, 50% glycerol, pH7.2.

Product Name Alternative

MAPT; Microtubule-associated protein tau; MTBT1; Neurofibrillary tangle protein; Paired helical filament-tau; PHF-tau

Swiss Prot

P10636

Reactivity

Human Mouse Rat

Immunogen

A synthesized peptide derived from human Phospho-Tau (T231)

Conjugation

Unconjugated

Applications

WB IHC IP

Dilution

WB 1:500~1:2000 IHC 1:50~1:200 IP 1:50

Purity

Affinity-chromatography

Modification

Phosphorylated

Molecular Weight

46kDa

Storage Conditions

Store at 4°C short term. Aliquot and store at -20°C long term. Avoid freeze-thaw cycles.

Notes

For research use only, not for use in diagnostic procedure.

Specificity

Phospho-Tau (T231) Antibody detects endogenous levels of Phospho-Tau (T231)

Applications Notes

Western blot analysis of Phospho-Tau (T231) expression in (1) SH-SY5Y cell lysate; (2) SH-SY5Y cell lysate, treated with sorbitol.

Host or Source

Rabbit

Available Sizes

More Discoveries

Explore Other Products

Browse additional items from our catalog

S676880 10 g

Sorbic Chloride

View Details

K3200705 3x 1.0 µg

Aknad1 sgRNA CRISPR/Cas9 All-in-One Lentivector set (Mouse)

View Details

MBS6416652-01 0.1 mL

FAAH (Fatty Acid Amide Hydrolase, FAAH1, MGC102823, MGC138146) (APC)

View Details

MBS6416652-02 5x 0.1 mL

FAAH (Fatty Acid Amide Hydrolase, FAAH1, MGC102823, MGC138146) (APC)

View Details

PV228179 500 ng

SERPINB7 Protein Vector (Mouse) (pPB-N-His)

View Details

sc-406536 20 µg

POPX2 CRISPR/Cas9 KO Plasmid (h)

View Details