Phospho-Tau (T231) Rabbit monoclonal antibody

Product Specifications

Background

Tau is a heterogeneous microtubule-associated protein that promotes and stabilizes microtubule assembly, especially in axons. Six isoforms with different amino-terminal inserts and different numbers of tandem repeats near the carboxy-terminus have been identified, and tau is hyperphosphorylated at approximately 25 sites by ERK, GSK-3 and CDK5. Phosphorylation decreases the ability of tau to bind to microtubules. Neurofibrillary tangles are a major hallmark of Alzheimer's disease and these tangles are bundles of paired helical filaments composed of hyperphosphorylated tau.

CAS Number

9007-83-4

Structure Composition

Rabbit IgG, 1mg/ml in PBS with 0.02% sodium azide, 50% glycerol, pH7.2.

Product Name Alternative

MAPT; Microtubule-associated protein tau; MTBT1; Neurofibrillary tangle protein; Paired helical filament-tau; PHF-tau

Swiss Prot

P10636

Reactivity

Human Mouse Rat

Immunogen

A synthesized peptide derived from human Phospho-Tau (T231)

Conjugation

Unconjugated

Applications

WB IHC IP

Dilution

WB 1:500~1:2000 IHC 1:50~1:200 IP 1:50

Purity

Affinity-chromatography

Modification

Phosphorylated

Molecular Weight

46kDa

Storage Conditions

Store at 4°C short term. Aliquot and store at -20°C long term. Avoid freeze-thaw cycles.

Notes

For research use only, not for use in diagnostic procedure.

Specificity

Phospho-Tau (T231) Antibody detects endogenous levels of Phospho-Tau (T231)

Applications Notes

Western blot analysis of Phospho-Tau (T231) expression in (1) SH-SY5Y cell lysate; (2) SH-SY5Y cell lysate, treated with sorbitol.

Host or Source

Rabbit

Available Sizes

More Discoveries

Explore Other Products

Browse additional items from our catalog

TA374502 100 µL

CDC27 Rabbit Polyclonal Antibody

View Details

NBL1-17819 0.1 mg

WDR54 Overexpression Lysate (Native) - (Dry Ice)

View Details

K3016005 3x 1.0 µg

Vmn2r40 sgRNA CRISPR/Cas9 All-in-One Lentivector set (Mouse)

View Details

MBS9324553-01 48 Well

Human Valyl-tRNA synthetase, mitochondrial, VARS2 ELISA Kit

View Details

MBS9324553-02 96 Well

Human Valyl-tRNA synthetase, mitochondrial, VARS2 ELISA Kit

View Details

MBS9324553-03 5x 96 Well

Human Valyl-tRNA synthetase, mitochondrial, VARS2 ELISA Kit

View Details