Phospho-Tau (T231) Rabbit monoclonal antibody

Product Specifications

Background

Tau is a heterogeneous microtubule-associated protein that promotes and stabilizes microtubule assembly, especially in axons. Six isoforms with different amino-terminal inserts and different numbers of tandem repeats near the carboxy-terminus have been identified, and tau is hyperphosphorylated at approximately 25 sites by ERK, GSK-3 and CDK5. Phosphorylation decreases the ability of tau to bind to microtubules. Neurofibrillary tangles are a major hallmark of Alzheimer's disease and these tangles are bundles of paired helical filaments composed of hyperphosphorylated tau.

CAS Number

9007-83-4

Structure Composition

Rabbit IgG, 1mg/ml in PBS with 0.02% sodium azide, 50% glycerol, pH7.2.

Product Name Alternative

MAPT; Microtubule-associated protein tau; MTBT1; Neurofibrillary tangle protein; Paired helical filament-tau; PHF-tau

Swiss Prot

P10636

Reactivity

Human Mouse Rat

Immunogen

A synthesized peptide derived from human Phospho-Tau (T231)

Conjugation

Unconjugated

Applications

WB IHC IP

Dilution

WB 1:500~1:2000 IHC 1:50~1:200 IP 1:50

Purity

Affinity-chromatography

Modification

Phosphorylated

Molecular Weight

46kDa

Storage Conditions

Store at 4°C short term. Aliquot and store at -20°C long term. Avoid freeze-thaw cycles.

Notes

For research use only, not for use in diagnostic procedure.

Specificity

Phospho-Tau (T231) Antibody detects endogenous levels of Phospho-Tau (T231)

Applications Notes

Western blot analysis of Phospho-Tau (T231) expression in (1) SH-SY5Y cell lysate; (2) SH-SY5Y cell lysate, treated with sorbitol.

Host or Source

Rabbit

Available Sizes

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