Phospho-p53 (S376) Rabbit monoclonal antibody
Product Specifications
Background
Plays an essential role in the regulation of cell cycle, specifically in the transition from G0 to G1. It is found in very low levels in normal cells, however, in a variety of transformed cell lines, it is expressed in high amounts, and believed to contribute to transformation and malignancy. p53 is a DNA-binding protein containing DNA-binding, oligomerization and transcription activation domains. It is postulated to bind as a tetramer to a p53-binding site and activate expression of downstream genes that inhibit growth and/or invasion, and thus function as a tumor suppressor.
CAS Number
9007-83-4
Structure Composition
Rabbit IgG, 1mg/ml in PBS with 0.02% sodium azide, 50% glycerol, pH7.2.
Product Name Alternative
Antigen NY-CO-13, Cellular tumor antigen p53, Phosphoprotein p53, TP53, Tumor suppressor p53
Swiss Prot
P04637
Reactivity
Human
Immunogen
A synthesized peptide derived from human Phospho-p53 (S376)
Conjugation
Unconjugated
Applications
WB
Dilution
WB 1:500~1:2000
Purity
Affinity-chromatography
Modification
Phosphorylated
Molecular Weight
53kDa
Storage Conditions
Store at 4°C short term. Aliquot and store at -20°C long term. Avoid freeze-thaw cycles.
Notes
For research use only, not for use in diagnostic procedure.
Specificity
Phospho-p53 (S376) Antibody detects endogenous levels of total Phospho-p53 (S376)
Applications Notes
Western blot analysis of Phospho-p53 (S376) in HEK293 cell lysates treated with Calyculin A and Okadaic Acid.
Host or Source
Rabbit
Available Sizes
Curated Selection
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