Cyclin D1 Rabbit monoclonal antibody
Product Specifications
Background
Phosphorylation of RB1 allows dissociation of the transcription factor E2F from the RB/E2F complex and the subsequent transcription of E2F target genes which are responsible for the progression through the G1 phase. Hypophosphorylates RB1 in early G1 phase. Cyclin D-CDK4 complexes are major integrators of various mitogenenic and antimitogenic signals.
CAS Number
9007-83-4
Structure Composition
Rabbit IgG, 1mg/ml in PBS with 0.02% sodium azide, 50% glycerol, pH7.2.
Product Name Alternative
CCND1; BCL1; D11S287E; PRAD1; U21B31; Cyclin D1
Swiss Prot
P24385
Reactivity
Human Mouse Rat
Immunogen
A synthesized peptide derived from human Cyclin D1
Conjugation
Unconjugated
Applications
WB IHC ICC/IF IP
Dilution
WB 1:1000~1:5000 IHC 1:50~1:200 ICC/IF 1:50~1:100 IP 1:50
Purity
Affinity-chromatography
Modification
Unmodified
Molecular Weight
~ 35 kDa
Storage Conditions
Store at 4°C short term. Aliquot and store at -20°C long term. Avoid freeze-thaw cycles.
Notes
For research use only, not for use in diagnostic procedure.
Specificity
Cyclin D1 Antibody detects endogenous levels of total Cyclin D1
Applications Notes
Western blot (WB) analysis of Cyclin D1 Rabbit monoclonal antibody at 1:500 dilution Lane1:MCF-7 whole cell lysate (30ug) Lane2:A431 whole cell lysate (30ug) Lane3:The Liver tissue lysate of Mouse (30ug) Lane4:The Lung tissue lysate of Rat (30ug)
Host or Source
Rabbit
Available Sizes
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