LGR5/GPR49 Rabbit monoclonal antibody
Product Specifications
Background
Receptor for R-spondins that potentiates the canonical Wnt signaling pathway and acts as a stem cell marker of the intestinal epithelium and the hair follicle. Upon binding to R-spondins (RSPO1, RSPO2, RSPO3 or RSPO4), associates with phosphorylated LRP6 and frizzled receptors that are activated by extracellular Wnt receptors, triggering the canonical Wnt signaling pathway to increase expression of target genes.
CAS Number
9007-83-4
Structure Composition
Rabbit IgG, 1mg/ml in PBS with 0.02% sodium azide, 50% glycerol, pH7.2.
Product Name Alternative
FEX; GPR49; GPR67; GRP49; LGR5; HG38;8
Swiss Prot
O75473
Reactivity
Human Mouse Rat
Immunogen
A synthesized peptide derived from human LGR5/GPR49
Conjugation
Unconjugated
Applications
WB IP FC
Dilution
WB 1:500~1:2000 IP 1:50 FC 1:200
Purity
Affinity-chromatography
Modification
Unmodified
Molecular Weight
100kDa
Storage Conditions
Store at 4°C short term. Aliquot and store at -20°C long term. Avoid freeze-thaw cycles.
Notes
For research use only, not for use in diagnostic procedure.
Specificity
LGR5/GPR49 Antibody detects endogenous levels of total LGR5/GPR49
Applications Notes
Western blot analysis of GPR49 expression in Human fetal skeletal muscle lysate.
Host or Source
Rabbit
Available Sizes
Curated Selection
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