Cathepsin D Rabbit monoclonal antibody
Product Specifications
Background
This gene encodes a lysosomal aspartyl protease composed of a dimer of disulfide-linked heavy and light chains, both produced from a single protein precursor. This proteinase, which is a member of the peptidase C1 family, has a specificity similar to but narrower than that of pepsin A. Transcription of this gene is initiated from several sites, including one which is a start site for an estrogen-regulated transcript. Mutations in this gene are involved in the pathogenesis of several diseases, including breast cancer and possibly Alzheimer disease.
CAS Number
9007-83-4
Structure Composition
Rabbit IgG, 1mg/ml in PBS with 0.02% sodium azide, 50% glycerol, pH7.2.
Product Name Alternative
CATD; Cathepsin D; Cathepsin D heavy chain; Cathepsin D light chain; ceroid-lipofuscinosis, neuronal 10; CLN10; CPSD; CTSD; lysosomal aspartyl peptidase; lysosomal aspartyl protease; MGC2311
Swiss Prot
P07339
Reactivity
Human Mouse Rat
Immunogen
A synthesized peptide derived from human Cathepsin D
Conjugation
Unconjugated
Applications
WB IHC ICC/IF IP FC
Dilution
WB 1:500~1:2000 IHC 1:50~1:200 ICC/IF 1:50~1:200 IP 1:50 FC 1:20
Purity
Affinity-chromatography
Modification
Unmodified
Molecular Weight
46kDa/28kDa
Storage Conditions
Store at 4°C short term. Aliquot and store at -20°C long term. Avoid freeze-thaw cycles.
Notes
For research use only, not for use in diagnostic procedure.
Specificity
Cathepsin D Antibody detects endogenous levels of total Cathepsin D
Applications Notes
Western blot analysis of Cathepsin D expression in (1) MCF-7 cell lysate; (2) SKBR-3 cell lysate.
Host or Source
Rabbit
Available Sizes
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