PI 3 kinase p110 alpha Rabbit monoclonal antibody

Product Specifications

Background

Phosphoinositide-3-kinase (PI3K) that phosphorylates PtdIns (Phosphatidylinositol), PtdIns4P (Phosphatidylinositol 4-phosphate) and PtdIns (4,5) P2 (Phosphatidylinositol 4,5-bisphosphate) to generate phosphatidylinositol 3,4,5-trisphosphate (PIP3) . PIP3 plays a key role by recruiting PH domain-containing proteins to the membrane, including AKT1 and PDPK1, activating signaling cascades involved in cell growth, survival, proliferation, motility and morphology. Participates in cellular signaling in response to various growth factors.

CAS Number

9007-83-4

Structure Composition

Rabbit IgG, 1mg/ml in PBS with 0.02% sodium azide, 50% glycerol, pH7.2.

Product Name Alternative

PI 3 Kinase catalytic subunit alpha; phosphoinositide-3-kinase catalytic alpha polypeptide; PI3-kinase p110 alpha; PI3K; PI3K p110-alpha; PK3CA; PIK3CA; PtdIns-3-kinase p110

Swiss Prot

P42336

Reactivity

Human Mouse Rat

Immunogen

A synthesized peptide derived from human PI 3 Kinase catalytic subunit alpha

Conjugation

Unconjugated

Applications

WB ICC/IF IP

Dilution

WB 1:1000~1:2000 ICC/IF 1:50~1:200 IP 1:20

Purity

Affinity-chromatography

Modification

Unmodified

Molecular Weight

110kDa

Storage Conditions

Store at 4°C short term. Aliquot and store at -20°C long term. Avoid freeze-thaw cycles.

Notes

For research use only, not for use in diagnostic procedure.

Specificity

PI 3 Kinase catalytic subunit alpha detects endogenous levels of total PI 3 Kinase catalytic subunit alpha

Applications Notes

Western blot analysis of PI 3 kinase p110 alpha expression in Jurkat cell lysate.Western blot analysis of PI 3 kinase p110 alpha expression in Jurkat cell lysate.