Phospho-alpha Synuclein (S129) Rabbit monoclonal antibody

Product Specifications

Background

SNCA a member of the synuclein family. Abundantly expressed in the brain. Inhibits phospholipase D2 selectively. May integrate presynaptic signaling and membrane trafficking. Implicated in the pathogenesis of Parkinson's disease. A major component of amyloid plaques in the brains of patients with Alzheimer's disease. Two alternatively spliced isoforms transcripts have been identified.

CAS Number

9007-83-4

Structure Composition

Rabbit IgG, 1mg/ml in PBS with 0.02% sodium azide, 50% glycerol, pH7.2.

Product Name Alternative

Alpha-synuclein; NACP; non A-beta component of AD amyloid; PARK1; PARK4; PD1; SNCA

Swiss Prot

P37840

Reactivity

Human

Immunogen

A synthesized peptide derived from human Phospho-alpha Synuclein (S129)

Conjugation

Unconjugated

Applications

WB IHC ICC/IF

Dilution

WB 1:500~1:2000 IHC 1:50~1:200 ICC/IF 1:50~1:200

Purity

Affinity-chromatography

Modification

Phosphorylated

Molecular Weight

18kDa

Storage Conditions

Store at 4°C short term. Aliquot and store at -20°C long term. Avoid freeze-thaw cycles.

Notes

For research use only, not for use in diagnostic procedure.

Specificity

Phospho-alpha Synuclein (S129) Antibody detects endogenous levels of total Phospho-alpha Synuclein (S129)

Applications Notes

Western blot analysis of Phospho-alpha Synuclein (Ser129) expression in (1) 293T cell lysate; (2) 293T cell lysate transfected with Polo-Like Kinase 2 and alpha Synuclein.