Phospho-LAT (Y220) Rabbit monoclonal antibody
Product Specifications
Background
Required for TCR (T-cell antigen receptor) - and pre-TCR-mediated signaling, both in mature T-cells and during their development. Involved in FCGR3 (low affinity immunoglobulin gamma Fc region receptor III) -mediated signaling in natural killer cells and FCER1 (high affinity immunoglobulin epsilon receptor) -mediated signaling in mast cells. Couples activation of these receptors and their associated kinases with distal intracellular events such as mobilization of intracellular calcium stores, PKC activation, MAPK activation or cytoskeletal reorganization through the recruitment of PLCG1, GRB2, GRAP2, and other signaling molecules.
CAS Number
9007-83-4
Structure Composition
Rabbit IgG, 1mg/ml in PBS with 0.02% sodium azide, 50% glycerol, pH7.2.
Product Name Alternative
36 kDa phospho-tyrosine adaptor protein; LAT1; lat; pp36
Swiss Prot
O43561
Reactivity
Human Mouse Rat
Immunogen
A synthesized peptide derived from human Phospho-LAT (Y220)
Conjugation
Unconjugated
Applications
WB IHC ICC/IF IP
Dilution
WB 1:500~1:2000 IHC 1:50~1:200 ICC/IF 1:50~1:200 IP 1:30
Purity
Affinity-chromatography
Modification
Phosphorylated
Molecular Weight
38kDa
Storage Conditions
Store at 4°C short term. Aliquot and store at -20°C long term. Avoid freeze-thaw cycles.
Notes
For research use only, not for use in diagnostic procedure.
Specificity
Phospho-LAT LAT (Y220) Antibody detects endogenous levels of total Phospho-LAT (Y220)
Applications Notes
Western blot analysis of Phospho-LAT (Y220) in Jurkat cell treated with CD3 lysate.
Host or Source
Rabbit
Available Sizes
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