SR-1903
SR-1903 is an inverse agonist of RORγ and PPARγ (IC50 of ∼100 nM and 209 nM for RORγ and PPARγ, respectively) and a LXR agonist. SR-1903 exhibits anti-inflammatory and anti-diabetic efficacy in collagen-induced arthritis and diet-induced obesity mouse models[1].
Product Specifications
CAS Number
1414248-06-8
UNSPSC
12352005
Target
LXR; PPAR; ROR
Type
Reference compound
Related Pathways
Cell Cycle/DNA Damage; Metabolic Enzyme/Protease; Vitamin D Related/Nuclear Receptor
Field of Research
Metabolic Disease; Inflammation/Immunology
Assay Protocol
https://www.medchemexpress.com/sr-1903.html
Smiles
OC(C(F)(F)F)(C(F)(F)F)C1=CC=C(C2=CC=C(CN3CCN(CC4=CC=NC=C4)CC3)C=C2C)C=C1
Molecular Formula
C27H27F6N3O
Molecular Weight
523.51
References & Citations
[1] Chang MR, et al. Unique Polypharmacology Nuclear Receptor Modulator Blocks Inflammatory Signaling Pathways. ACS Chem Biol. 2019, 14 (5) :1051-1062.
Shipping Conditions
Room temperature
Scientific Category
Reference compound1
Clinical Information
No Development Reported
Isoform
PPARγ; RORγ
Available Sizes
Frequently Asked Questions
More Discoveries
Explore Other Products
Browse additional items from our catalog
GTR15277374 1 Vial
Lentiviral mouse Zfp800 shRNA (UAS) - Lentiviral mouse Zfp800 shRNA (UAS) (100)
Sign In for Pricing
View Details orb927587 100 µL
QARS/Glutamyl Prolyl tRNA synthetase/ProRS Rabbit Polyclonal Antibody (PE-Cy7)
Sign In for Pricing
View Details