IL21 polyclonal antibody
Product Specifications
Background
Cytokine with immunoregulatory activity. May promote the transition between innate and adaptive immunity. Induces the production of IgG1 and IgG3 in B-cells (By similarity) . Implicated in the generation and maintenance of T follicular helper (Tfh) cells and the formation of germinal-centers. Together with IL6, control the early generation of Tfh cells and are critical for an effective antibody response to acute viral infection (By similarity) . May play a role in proliferation and maturation of natural killer (NK) cells in synergy with IL15. May regulate proliferation of mature B- and T-cells in response to activating stimuli. In synergy with IL15 and IL18 stimulates interferon gamma production in T-cells and NK cells. During T-cell mediated immune response may inhibit dendritic cells (DC) activation and maturation (By similarity) .
CAS Number
9007-83-4
Structure Composition
Rabbit IgG, 1mg/ml in PBS with 0.02% sodium azide, 50% glycerol, pH7.2.
Product Name Alternative
Interleukin-21; IL-21; Za11; IL21
Swiss Prot
Q9HBE4
Reactivity
Human, Mouse
Immunogen
Recombinant protein of human IL21.
Conjugation
Unconjugated
Applications
WB
Dilution
WB 1:1000~1:2000
Purity
The antibody was affinity-purified from rabbit antiserum by affinity-chromatography using epitope-specific immunogen and the purity is > 95% (by SDS-PAGE) .
Modification
Unmodified
Molecular Weight
~ 19 kDa
Storage Conditions
Store at 4°C short term. Aliquot and store at -20°C long term. Avoid freeze-thaw cycles.
Notes
For research use only, not for use in diagnostic procedure.
Specificity
IL21 polyclonal antibody detects endogenous levels of IL21 protein.
Applications Notes
Western blot (WB) analysis of IL21 polyclonal antibody at 1:1000 dilution Lane1:RAW264.7 whole cell lysate (30ug) Lane2:K562 whole cell lysate (30ug) Lane3:Jurkat whole cell lysate (30ug)
Host or Source
Rabbit
Available Sizes
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