CATSPER1 polyclonal antibody
Product Specifications
Background
CatSper is an ion transport protein located on the surface of sperm cells. CatSper (for cation channel of sperm) is vital to cAMP-mediated calcium influx in sperm, sperm motility and fertilization. The gene that encodes CatSper maps to human chromosome 11q12.1. The 686 amino acid protein is a single, six-transmembrane-spanning protein of the voltage- dependent Ca2+ channel four-repeat structure and is expressed exclusively in the testis. In CatSper -/- sperm, neither cAMP nor cGMP elicit a significant Ca2+ influx in both mutant and wild-type sperm. CatSper is localized to the sperm flagellum and CatSper -/- mice show sluggish and less directed movements. CatSper is required to penetrate the egg, but is not required for egg activation.
CAS Number
9007-83-4
Structure Composition
Rabbit IgG, 1mg/ml in PBS with 0.02% sodium azide, 50% glycerol, pH7.2
Product Name Alternative
Cation channel sperm-associated protein 1; CatSper1; hCatSper; CATSPER1
Swiss Prot
Q8NEC5
Reactivity
Human, Mouse
Immunogen
A synthetic peptide corresponding to residues in Human CATSPER1
Conjugation
Unconjugated
Applications
WB IP
Dilution
WB: 1:500~1:2000 IP: 1:50~1:200
Purity
The antibody was affinity-purified from rabbit antiserum by affinity-chromatography using epitope-specific immunogen and the purity is > 95% (by SDS-PAGE) .
Modification
Unmodified
Molecular Weight
~ 90 kDa
Storage Conditions
Store at 4°C short term. Aliquot and store at -20°C long term. Avoid freeze-thaw cycles.
Notes
For research use only, not for use in diagnostic procedure.
Specificity
CATSPER1 polyclonal antibody detects endogenous levels of CATSPER1 protein.
Applications Notes
Western blot (WB) analysis of CATSPER1 polyclonal antibody at 1:1000 dilution Lane1:A549 whole cell lysate Lane2:Hela whole cell lysate Lane3:SP2/0 whole cell lysate
Host or Source
Rabbit
Available Sizes
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