STING/TMEM173 polyclonal antibody
Product Specifications
Background
This gene encodes a five transmembrane protein that functions as a major regulator of the innate immune response to viral and bacterial infections. The encoded protein is a pattern recognition receptor that detects cytosolic nucleic acids and transmits signals that activate type I interferon responses. The encoded protein has also been shown to play a role in apoptotic signaling by associating with type II major histocompatibility complex. Mutations in this gene are the cause of infantile-onset STING-associated vasculopathy. Alternate splicing results in multiple transcript variants.
CAS Number
9007-83-4
Structure Composition
Rabbit IgG, 1mg/ml in PBS with 0.02% sodium azide, 50% glycerol, pH7.2
Product Name Alternative
ERIS; MPYS; Mita; STING; Tmem173; STING-beta; 2610307O08Rik
Swiss Prot
Q3TBT3
Reactivity
Human, Mouse, Rat
Immunogen
A synthetic peptide corresponding to a sequence within amino acids 280-371 of mouse STING. (NP_938023.1) .
Conjugation
Unconjugated
Applications
WB IHC-P
Dilution
WB 1:500-1:1000 IHC-P 1:50-1:200
Purity
The antibody was affinity-purified from rabbit antiserum by affinity-chromatography using epitope-specific immunogen and the purity is > 95% (by SDS-PAGE) .
Modification
Unmodified
Molecular Weight
~ 33, 35 kDa
Storage Conditions
Store at 4°C short term. Aliquot and store at -20°C long term. Avoid freeze-thaw cycles.
Notes
For research use only, not for use in diagnostic procedure.
Specificity
STING/TMEM173 polyclonal antibody detects endogenous levels of STING/TMEM173 protein.
Applications Notes
Western blot analysis of various lysates using STING pAb at 1:1000 dilution.
Host or Source
Rabbit
Available Sizes
Curated Selection
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