Cathepsin H HC (N292) polyclonal antibody
Product Specifications
Background
Cathepsin H (also designated N-benzoylarginine-β-naphthylamide hydrolase, aleurain, cathepsin B3 or cathepsin BA) is a lysosomal cysteine proteinase that mediates degradation of lysosomal proteins. Cathepsin H is a disulfidelinked heavy and light chain dimer produced from a single precursor protein. The encoded protein, which belongs to the peptidase C1 protein family, can act both as an aminopeptidase and as an endopeptidase. Elevated levels of cathepsin H correlates with malignant progression of prostate tumors. Two transcript variants encoding different isoforms have been found for this gene. Full-length and truncated cathepsin H [12 amino acid deletion in the signal peptide region (CTSH∆10-21) ] are expressed in prostate tissues, LNCaP, PC-3 and DU-145 prostate cancer cell lines. Cathepsin H mediates maturation of the biologically active surfactant protein-B (SP-B) peptide.
CAS Number
9007-83-4
Structure Composition
Rabbit IgG, 1mg/ml in PBS with 0.02% sodium azide, 50% glycerol, pH7.2
Product Name Alternative
Pro-cathepsin H; Cathepsin H mini chain; Cathepsin H; Cathepsin H heavy chain; Cathepsin H light chain; CTSH; CPSB
Swiss Prot
P09668
Reactivity
Human, Mouse, Rat
Immunogen
Synthetic peptide, corresponding to amino acids 240-292 of Human Cathepsin H HC.
Conjugation
Unconjugated
Applications
WB
Dilution
WB: 1:1000~1:2000
Purity
The antibody was affinity-purified from rabbit antiserum by affinity-chromatography using epitope-specific immunogen and the purity is > 95% (by SDS-PAGE) .
Modification
Unmodified
Molecular Weight
~ 26 kDa
Storage Conditions
Store at 4°C short term. Aliquot and store at -20°C long term. Avoid freeze-thaw cycles.
Notes
For research use only, not for use in diagnostic procedure.
Specificity
Cathepsin H HC (N292) polyclonal antibody detects endogenous levels of Cathepsin H HC protein.
Applications Notes
Western blot (WB) analysis of Cathepsin H HC (N292) polyclonal antibody at 1:1000 dilution Lane1:SGC7901 whole cell lysate (40ug) Lane2:A549 whole cell lysate (40ug) Lane3:The Lung tissue lysate of Mouse (40ug) Lane4:The Lung tissue lysate of Rat (40ug) Lane5:HuT78 whole cell lysate (40ug)
Host or Source
Rabbit
Available Sizes
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