RPS19BP1 polyclonal antibody

Product Specifications

Background

S19BP, also known as RPS19BP1 (ribosomal protein S19 binding protein 1) or AROS, is a 136 amino acid protein that localizes to the nucleolus and belongs to the AROS family. Expressed in a variety of tissues, S19BP interacts with Ribosomal Protein S19 and SIRT1 and is thought to directly regulate SIRT1 function, specifically enhancing the SIRT1-mediated deacetylation of p53 and inhibiting p53-induced transcriptional activity. The gene encoding S19BP maps to human chromosome 22, which houses over 500 genes and is the second smallest human chromosome. Mutations in several of the genes that map to chromosome 22 are involved in the development of Phelan-McDermid syndrome, Neurofibromatosis type 2, autism and schizophrenia.

CAS Number

9007-83-4

Structure Composition

Rabbit IgG, 1mg/ml in PBS with 0.02% sodium azide, 50% glycerol, pH7.2

Product Name Alternative

Active regulator of SIRT1; 40S ribosomal protein S19-binding protein 1; RPS19-binding protein 1; S19BP; RPS19BP1; AROS

Swiss Prot

Q86WX3

Reactivity

Human

Immunogen

A synthetic peptide corresponding to residues in Human RPS19BP1.

Conjugation

Unconjugated

Applications

WB IP

Dilution

WB: 1:500~1:1000 IP: 1:50~1:200

Purity

The antibody was affinity-purified from rabbit antiserum by affinity-chromatography using epitope-specific immunogen and the purity is > 95% (by SDS-PAGE) .

Modification

Unmodified

Molecular Weight

~ 15 kDa

Storage Conditions

Store at 4°C short term. Aliquot and store at -20°C long term. Avoid freeze-thaw cycles.

Notes

For research use only, not for use in diagnostic procedure.

Specificity

RPS19BP1 polyclonal antibody detects endogenous levels of RPS19BP1 protein.

Applications Notes

Western blot (WB) analysis of RPS19BP1 pAb at 1:500 dilution Lane1:HCT116 whole cell lysate (40ug) Lane2:H1792 whole cell lysate (40ug) Lane3:EC9706 whole cell lysate (40ug) Lane4:A549 whole cell lysate (40ug)