PRDM10 polyclonal antibody

Product Specifications

Background

The PR-domain containing proteins (PRDMs) have a common involvement in the modulation of gene activities. A PR-domain family member usually produces two products, which differ by the presence or absence of the PR domain. The PR-plus product is underexpressed or disrupted, whereas the PR-minus product is present or overexpressed in cancer cells. This imbalance in the amount of the two products, which is a result of either genetic or epigenetic events, appears to be a determining cause of malignancy. PRDM10 (PR domain containing 10), also known as PFM7 or TRIS, is a 1,147 amino acid protein that contains ten C2H2-type zinc fingers and one SET domain. Existing as six alternatively spliced isoforms, PRDM10 localizes nucleus and may be involved in transcriptional regulation. PRDM10 may also play a role in the development of the central nerve system, as well as in the pathogenesis of neuronal storage disease.

CAS Number

9007-83-4

Structure Composition

Rabbit IgG, 1mg/ml in PBS with 0.02% sodium azide, 50% glycerol, pH7.2

Product Name Alternative

PR domain zinc finger protein 10; PR domain-containing protein 10; Tristanin; PRDM10; KIAA1231; PFM7; TRIS

Swiss Prot

Q9NQV6

Reactivity

Human, Rat

Immunogen

A synthetic peptide corresponding to residues in Human PRDM10

Conjugation

Unconjugated

Applications

Dilution

WB: 1:500~1:1000

Purity

The antibody was affinity-purified from rabbit antiserum by affinity-chromatography using epitope-specific immunogen and the purity is > 95% (by SDS-PAGE) .

Modification

Unmodified

Molecular Weight

~ 130 kDa

Storage Conditions

Store at 4°C short term. Aliquot and store at -20°C long term. Avoid freeze-thaw cycles.

Notes

For research use only, not for use in diagnostic procedure.

Specificity

PRDM10 polyclonal antibody detects endogenous levels of PRDM10 protein.

Applications Notes

Western blot (WB) analysis of PRDM10 pAb at 1:500 dilution Lane1:The Testis tissue lysate of Rat (40ug) Lane2:A375 whole cell lysate (40ug) Lane3:A2780 whole cell lysate (40ug) Lane4:SGC7901 whole cell lysate (40ug)