AChRα7 polyclonal antibody
Product Specifications
Background
Chromosome 15 encodes over 700 genes and comprises nearly 3% of the human genome. CHRFAM7A, a fusion protein comprised of FAM7A and AChRα7, is encoded by the CHRFAM7A gene, which is located on a region of human chromosome 15 that is associated with several neuropsychiatric disorders, such as schizophrenia and bipolar affective disorder. CHRFAM7A, also known as D-10 or CHRNA7, is a 412 amino acid multi-pass membrane protein that belongs to the nicotinic acetylcholine receptor (nAChR) subfamily of ligand-gated ion channel proteins, a protein superfamily that mediates signal transmission at synapses. CHRFAM7A is expressed in the hippocampus. Alternative splicing of the CHRFAM7A gene produces two splice variants.
CAS Number
9007-83-4
Structure Composition
Rabbit IgG, 1mg/ml in PBS with 0.02% sodium azide, 50% glycerol, pH7.2
Product Name Alternative
Neuronal acetylcholine receptor subunit alpha-7; CHRNA7; NACHRA7; CHRNA7-FAM7A fusion protein; CHRNA7-DR1; D-10; CHRFAM7A
Swiss Prot
P36544/Q494W8
Reactivity
Human, Mouse, Rat
Immunogen
Recombinant protein
Conjugation
Unconjugated
Applications
WB
Dilution
WB: 1:5000~1:1000 0
Purity
The antibody was affinity-purified from rabbit antiserum by affinity-chromatography using epitope-specific immunogen and the purity is > 95% (by SDS-PAGE) .
Modification
Unmodified
Molecular Weight
~ 56 kDa
Storage Conditions
Store at 4°C short term. Aliquot and store at -20°C long term. Avoid freeze-thaw cycles.
Notes
For research use only, not for use in diagnostic procedure.
Specificity
AChRα7 polyclonal antibody detects endogenous levels of AChRα7 protein.
Applications Notes
Western blot (WB) analysis of AChRα7 pAb at 1:5000 dilution Lane1:PC12 whole cell lysate (40ug) Lane2:AML-12 whole cell lysate (40ug) Lane3:HCT116 whole cell lysate (40ug) Lane4:EC9706 whole cell lysate (40ug) Lane5:SGC7901 whole cell lysate (40ug) Lane6:A549 whole cell lysate (40ug) Lane7:HEK293T whole cell lysate (40ug) Lane8:HepG2 whole cell lysate (40ug)
Host or Source
Rabbit
Available Sizes
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