Radixin polyclonal antibody
Product Specifications
Background
Ezrin, Moesin and Radixin belong to a family of highly homologous actin-associated proteins that are localized just beneath the plasma membrane. The proteins are believed to be involved in the mediation of interactions between cytoskeletal and membrane proteins. Ezrin serves as a major cytoplasmic substrate of various protein-tyrosine kinases, including the epidermal growth factor receptor. Ezrin has also been identified as a cAMP-dependent protein kinase (A-kinase) anchoring protein and designated AKAP78. Moesin and Radixin share over 70% homology with Ezrin and are co-expressed within various cell types. Despite the high degree of homology, the three proteins exhibit a distinct receptor-specific pattern of phosphorylation.
CAS Number
9007-83-4
Structure Composition
Rabbit IgG, 1mg/ml in PBS with 0.02% sodium azide, 50% glycerol, pH7.2
Product Name Alternative
RDX
Swiss Prot
P35241
Reactivity
Human, Mouse, Rat
Immunogen
Synthetic peptide, corresponding to amino acids 185-230 of Human Radixin.
Conjugation
Unconjugated
Related Pathways
Contribution of ECM and Cytoskeletal Factors to EMT
Applications
WB
Dilution
WB: 1:500~1:1000
Purity
The antibody was affinity-purified from rabbit antiserum by affinity-chromatography using epitope-specific immunogen and the purity is > 95% (by SDS-PAGE) .
Modification
Unmodified
Molecular Weight
~ 80-90 kDa
Storage Conditions
Store at 4°C short term. Aliquot and store at -20°C long term. Avoid freeze-thaw cycles.
Notes
For research use only, not for use in diagnostic procedure.
Specificity
Radixin polyclonal antibody detects endogenous levels of Radixin protein.
Applications Notes
Western blot (WB) analysis of Radixin (W175) pAb at 1:2000 dilution Lane1:SGC7901 whole cell lysate (40ug) Lane2:L02 whole cell lysate (40ug) Lane3:The Liver tissue lysate of Rat (40ug) Lane4:The Kidney tissue lysate of Mouse (40ug)
Host or Source
Rabbit
Available Sizes
Frequently Asked Questions
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