ZC3H8 polyclonal antibody
Product Specifications
Background
Zinc-finger CCCH domain-containing protein 8 (ZC3H8) acts as a transcriptional repressor of the GATA3 promoter. It is a sequence-specific DNA-binding factor that binds to the 5'-AGGTCTC-3' sequence within the negative cis-acting element intronic regulatory region (IRR) of the GATA3 gene (by similarity) . ZC3H8 induces thymocyte apoptosis when overexpressed, which may indicate a role in regulation of thymocyte homeostasis.
CAS Number
9007-83-4
Structure Composition
Rabbit IgG, 1mg/ml in PBS with 0.02% sodium azide, 50% glycerol, pH7.2
Product Name Alternative
Zinc finger CCCH domain-containing protein 8; ZC3HDC8
Swiss Prot
Q8N5P1
Reactivity
Human, Mouse, Rat
Immunogen
Synthetic peptide, corresponding to amino acids 133-178 of Human ZC3H8.
Conjugation
Unconjugated
Applications
WB IHC
Dilution
WB: 1:500~1:1000 IHC: 1:50~1:200
Purity
The antibody was affinity-purified from rabbit antiserum by affinity-chromatography using epitope-specific immunogen and the purity is > 95% (by SDS-PAGE) .
Modification
Unmodified
Molecular Weight
~ 33 kDa
Storage Conditions
Store at 4°C short term. Aliquot and store at -20°C long term. Avoid freeze-thaw cycles.
Notes
For research use only, not for use in diagnostic procedure.
Specificity
ZC3H8 polyclonal antibody detects endogenous levels of ZC3H8 protein.
Applications Notes
Western blot (WB) analysis of ZC3H8 pAb at 1:500 dilution Lane1:HCT116 whole cell lysate (20ug) Lane2:Hela whole cell lysate (20ug) Lane3:C6 whole cell lysate (40ug) Lane4:CT26 whole cell lysate (40ug)
Host or Source
Rabbit
Available Sizes
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