Synapsin I (phospho-S9) polyclonal antibody
Product Specifications
Background
Synapsin I is a member of the synapsin family. Synapsins are neuronal phosphoproteins which associate with the cytoplasmic surface of synaptic vesicles. Family members are characterized by common protein domains, and they are implicated in synaptogenesis and the modulation of neurotransmitter release, suggesting a potential role in several neuropsychiatric diseases. This member of the synapsin family plays a role in regulation of axonogenesis and synaptogenesis. The protein serves as a substrate for several different protein kinases and phosphorylation may function in the regulation of this protein in the nerve terminal. Mutations of the Synapsin I gene may be associated with X linked disorders with primary neuronal degeneration such as Rett syndrome.
CAS Number
9007-83-4
Structure Composition
Rabbit IgG, 1mg/ml in PBS with 0.02% sodium azide, 50% glycerol, pH7.2
Product Name Alternative
Synapsin-1; Synapsin 1; Synapsin1; Brain protein 4.1; Synapsin I; SYN1
Swiss Prot
P17600
Reactivity
Human, Mouse, Rat
Immunogen
Synthetic phosphopeptide derived from human Synapsin I around the phosphorylation site of Serine 9.
Conjugation
Unconjugated
Related Pathways
Neuronal and Glial Cell Marker Atlas
Applications
WB IHC IF
Dilution
WB: 1:500~1:1000 IHC: 1:50~1:200 IF: 1:50~1:200
Purity
The antibody was affinity-purified from rabbit antiserum by affinity-chromatography using epitope-specific immunogen and the purity is > 95% (by SDS-PAGE) .
Modification
Phosphorylated
Molecular Weight
~ 60-70 kDa
Storage Conditions
Store at 4°C short term. Aliquot and store at -20°C long term. Avoid freeze-thaw cycles.
Notes
For research use only, not for use in diagnostic procedure.
Specificity
P-Synapsin I (S9) polyclonal antibody detects endogenous levels of Synapsin I protein when phosphorylated at Ser9.
Applications Notes
Western blot (WB) analysis of p-Synapsin I (S9) pAb at 1:500 dilution Lane1:The Brain tissue lysate of Mouse (20ug) Lane2:The Brain tissue lysate of Rat (20ug)
Host or Source
Rabbit
Available Sizes
Frequently Asked Questions
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