Eg5 (phospho-T926) polyclonal antibody

Eg5 (also called kinesin-like protein 11 or Kif11) belongs to the kinesin-like family of motor proteins important in chromosome positioning, centrosome separation, and mitotic spindle formation. Phosphorylation of Eg5 by mitotic kinases regulates its activity by modulating its association with microtubules. Because anti-mitotic chemotherapeutic drugs, such as taxanes, target microtubules and have pleiotropic and sometimes toxic effects, drugs that target microtubule-associated proteins such as Eg5 are currently in development.

Kinesin-like protein KIF11; Kinesin-like protein 1; Kinesin-like spindle protein HKSP; Kinesin-related motor protein Eg5; Thyroid receptor-interacting protein 5; TR-interacting protein 5; TRIP-5; KIF11; EG5; KNSL1; TRIP5

The antibody was affinity-purified from rabbit antiserum by affinity-chromatography using epitope-specific immunogen and the purity is > 95% (by SDS-PAGE) .

Western blot (WB) analysis of p-Eg5 (T926) pAb at 1:500 dilution Lane1:HCT116 whole cell lysate (40µg) Lane2:HepG2 whole cell lysate (40µg) Lane3:CT-26 whole cell lysate (40µg) Lane4:C6 whole cell lysate (40µg) Lane5:LOVO whole cell lysate (40µg) Lane6:MCF-7 whole cell lysate (40µg)