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CD39 (K388) polyclonal antibody

Product Specifications

Background

CD39 is also weakly expressed on granulocytes. CD39 has homology to the Nmyc family of proteins and was recently cloned. CD39 can hydrolyze both nucleoside triphosphates and diphosphates. CD39 is the dominant ecto nucleotidase of vascular and placental trophoblastic tissues and appears to modulate the functional expression of type 2 purinergic (P2) G protein coupled receptors (GPCRs) . CD39 transgenic mice exhibit impaired platelet aggregation, prolonged bleeding times, and resistance to systemic thromboembolism. There is a correlation between ATP hydrolysis and triglycerides in patients with chronic heart disease, suggesting a relationship between ATP diphosphohydrolase and thrombogenesis.

CAS Number

9007-83-4

Structure Composition

Rabbit IgG, 1mg/ml in PBS with 0.02% sodium azide, 50% glycerol, pH7.2

Product Name Alternative

Ectonucleoside triphosphate diphosphohydrolase 1; NTPDase 1; Ecto-ATP diphosphohydrolase 1; Ecto-ATPDase 1; Ecto-ATPase 1; Ecto-apyrase; Lymphoid cell activation antigen; CD_antigen=CD39; ENTPD1; CD39

Swiss Prot

P49961

Reactivity

Human

Immunogen

Synthetic peptide, corresponding to amino acids 350-400 of Human CD391.

Conjugation

Unconjugated

Applications

WB

Dilution

WB: 1:500~1:1000

Purity

The antibody was affinity-purified from rabbit antiserum by affinity-chromatography using epitope-specific immunogen and the purity is > 95% (by SDS-PAGE) .

Modification

Unmodified

Molecular Weight

~ 65 kDa

Storage Conditions

Store at 4°C short term. Aliquot and store at -20°C long term. Avoid freeze-thaw cycles.

Notes

For research use only, not for use in diagnostic procedure.

Specificity

CD39 (K388) polyclonal antibody detects endogenous levels of CD39 protein.

Applications Notes

Western blot (WB) analysis of ENTPD1 pAb at 1:2000 dilution Lane1:A549 whole cell lysate (40ug) Lane2:HepG2 whole cell lysate (40ug) Lane3:SGC7901 whole cell lysate (40ug) Lane4:Myla2059 whole cell lysate (40ug) Lane5:A375 whole cell lysate (40ug)

Host or Source

Rabbit

Available Sizes

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