CB1 (F189) polyclonal antibody
Product Specifications
Background
The cannabinoid receptors (CB1 and CB2) are G-protein coupled receptors that inhibit adenylate cyclase activity in response to psychoactive cannabinoids. CB1 is expressed in brain tissue and, in low levels, in testis. Phosporylation of CB1 on serine 316 leads to a disruption of CB1-mediated inhibition of calcium channels and activation of potassium currents. This response system is thought to be involved in specific brain functions, such as nociception, control of movement, memory, and neuroendocrine regulation as well as having a possible role in brain development. In addition, CB1 may mediate the addictive behavior involved with the use of psychoactive cannabinoids, such as THC in marijuana.
CAS Number
9007-83-4
Structure Composition
Rabbit IgG, 1mg/ml in PBS with 0.02% sodium azide, 50% glycerol, pH7.2
Product Name Alternative
Cannabinoid receptor 1; CB-R; CB1; CANN6; CNR1; CNR
Swiss Prot
P21554
Reactivity
Human, Mouse, Rat
Immunogen
Synthetic peptide, corresponding to amino acids 150-200 of Human CB1.
Conjugation
Unconjugated
Applications
WB IHC
Dilution
WB: 1:500~1:1000 IHC: 1:50~1:200
Purity
The antibody was affinity-purified from rabbit antiserum by affinity-chromatography using epitope-specific immunogen and the purity is > 95% (by SDS-PAGE) .
Modification
Unmodified
Molecular Weight
~ 66 kDa
Storage Conditions
Store at 4°C short term. Aliquot and store at -20°C long term. Avoid freeze-thaw cycles.
Notes
For research use only, not for use in diagnostic procedure.
Specificity
CB1 (F189) polyclonal antibody detects endogenous levels of CB1 protein.
Applications Notes
Western blot (WB) analysis of CB1 (F189) pAb at 1:500 dilution Lane1:BV2 whole cell lysate (40ug) Lane2:The Brain tissue lysate of Rat (40ug) Lane3:A549 whole cell lysate (40ug) Lane4:U-87MG whole cell lysate (40ug)
Host or Source
Rabbit
Available Sizes
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