KOX17 (K22) polyclonal antibody

Product Specifications

Background

Zinc-finger proteins contain DNA-binding domains and have a wide variety of functions, most of which encompass some form of transcriptional activation or repression. The majority of zinc-finger proteins contain a Krueppel-type DNA binding domain and a KRAB domain, which is thought to interact with KAP1, thereby recruiting histone modifying proteins. ZNF191 (Zinc finger protein 191), also known as ZNF24, KOX17, ZSCAN3 or RSG-A, is a 368 amino acid nuclear protein that belongs to the Krueppel C2H2-type zinc-finger protein family. Expressed in tissues throughout the body with the exception of heart, ZNF191 functions as a transcriptional repressor for a variety of proteins, such as VEGF (vascular endothelial growth factor), and is thought to be important for early embryonic development and cell proliferation. ZNF191 contains four C2H2-type zinc fingers and one SCAN box domain and, upon DNA damage, may be phosphorylated by ATM or ATR.

CAS Number

9007-83-4

Structure Composition

Rabbit IgG, 1mg/ml in PBS with 0.02% sodium azide, 50% glycerol, pH7.2

Product Name Alternative

KOX17; Retinoic acid suppression protein A; RSG A; RSGA; Zfp191; Zinc finger and SCAN domain containing protein 3; Zinc finger protein 191; Zinc finger protein 24; Zinc finger protein KOX17; ZNF 24; ZNF191; ZSCAN 3; ZSCAN3

Swiss Prot

P17028

Reactivity

Human, Rat

Immunogen

Synthetic peptide, corresponding to the N-terminus of Human KOX17.

Conjugation

Unconjugated

Applications

WB IHC

Dilution

WB: 1:500~1:1000 IHC: 1:50~1:200

Purity

The antibody was affinity-purified from rabbit antiserum by affinity-chromatography using epitope-specific immunogen and the purity is > 95% (by SDS-PAGE) .

Modification

Unmodified

Molecular Weight

~ 42 kDa

Storage Conditions

Store at 4°C short term. Aliquot and store at -20°C long term. Avoid freeze-thaw cycles.

Notes

For research use only, not for use in diagnostic procedure.

Specificity

KOX17 (K22) polyclonal antibody detects endogenous levels of KOX17 protein.

Applications Notes

Western blot (WB) analysis of KOX17 (K22) pAb at 1:500 dilution Lane1:Hela whole cell lysate (40ug) Lane2:HEK293T whole cell lysate (40ug) Lane3:A549 whole cell lysate (40ug) Lane4:U-87MG whole cell lysate (40ug) Lane5:The Brain tissue lysate of Rat (10ug) Lane6:PC12 whole cell lysate (40ug)