FHIT (E116) polyclonal antibody
Product Specifications
Background
FHIT, a candidate tumor suppressor gene, contains the FRA3B common fragile site and is highly susceptible to carcinogen damage. The pattern of mutational inactivation seen with the FHIT gene is unique compared with other known tumor suppressors. FHIT gene structure and expression have been shown to be altered in esophageal, head, neck, lung, gastric, breast, and cervical carcinomas. It has been demonstrated that FHIT exon loss is associated with smoking duration or asbestos exposure. The FHIT protein is a member of the histidine triad (HIT) superfamily and functions as a dinucleoside 5’,5’’’-P1, P3-triphosphate hydrolase.
CAS Number
9007-83-4
Structure Composition
Rabbit IgG, 1mg/ml in PBS with 0.02% sodium azide, 50% glycerol, pH7.2
Product Name Alternative
Bis (5'-adenosyl) -triphosphatase; AP3A hydrolase; AP3Aase; Diadenosine 5',5'''-P1, P3-triphosphate hydrolase; Dinucleosidetriphosphatase; Fragile histidine triad protein; FHIT
Swiss Prot
P49789
Reactivity
Human, Mouse
Immunogen
Synthetic peptide, corresponding to amino acids 100-150 of Human FHIT.
Conjugation
Unconjugated
Applications
WB IHC IF IP
Dilution
WB: 1:500~1:1000 IHC: 1:50~1:200 IF: 1:50~1:200 IP: 1:50~1:200
Purity
The antibody was affinity-purified from rabbit antiserum by affinity-chromatography using epitope-specific immunogen and the purity is > 95% (by SDS-PAGE) .
Modification
Unmodified
Molecular Weight
~ 20 kDa
Storage Conditions
Store at 4°C short term. Aliquot and store at -20°C long term. Avoid freeze-thaw cycles.
Notes
For research use only, not for use in diagnostic procedure.
Specificity
FHIT (E116) polyclonal antibody detects endogenous levels of FHIT protein.
Applications Notes
Western blot (WB) analysis of FHIT (E116) pAb at 1:500 dilution Lane1:SK-OVCAR3 whole cell lysate (40ug) Lane2:The Kidney tissue lysate of Mouse (40ug) Lane3:MCF-7 whole cell lysate (40ug) Lane4:SGC7901 whole cell lysate (40ug)
Host or Source
Rabbit
Available Sizes
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