Neurofilament H polyclonal antibody
Product Specifications
Background
Neurofilaments are type IV intermediate filament heteropolymers composed of light, medium, and heavy chains. Neurofilaments comprise the axoskeleton and functionally maintain neuronal caliber. They may also play a role in intracellular transport to axons and dendrites. This gene encodes the heavy neurofilament protein. This protein is commonly used as a biomarker of neuronal damage and susceptibility to amyotrophic lateral sclerosis (ALS) has been associated with mutations in this gene.
CAS Number
9007-83-4
Structure Composition
1mg/ml in PBS with 0.02% sodium azide, 50% glycerol, pH7.2
Product Name Alternative
CMT2CC; NFH; NEFH
Swiss Prot
P12036
Reactivity
Human, Mouse, Rat
Immunogen
KLH-conjugated synthetic peptide encompassing a sequence within the C-term region of human Neurofilament H.
Conjugation
Unconjugated
Applications
WB, IHC, ICC
Dilution
WB,1:500 - 1:1000|IHC,1:50 - 1:200|IF/ICC,1:100 - 1:500
Purity
The antibody was affinity-purified from rabbit antiserum by affinity-chromatography using epitope-specific immunogen and the purity is > 95% (by SDS-PAGE) .
Modification
Unmodified
Molecular Weight
250KDa
Storage Conditions
Store at 4°C short term. Aliquot and store at -20°C long term. Avoid freeze-thaw cycles.
Notes
For research use only, not for use in diagnostic procedure.
Specificity
Neurofilament H polyclonal antibody detects endogenous levels of Neurofilament H protein.
Applications Notes
Western blot analysis of Neurofilament H expression in C6 (A), CT26 (B), HepG2 (C), A2780 (D) whole cell lysates.
Host or Source
Rabbit
Available Sizes
Frequently Asked Questions
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