INSL3 polyclonal antibody

Product Specifications

Background

Insulin-like factor 3 (INSL3), also designated Leydig insulin-like peptide (Ley IL) and Relaxin-like factor (RLF), is a peptide hormone in the Relaxin family which is secreted from the testicular Leydig cells and ovarian theca interna cells. INSL3 is involved in gonadal and other physiological processes. Structurally similar to Relaxin and insulin, INSL3 differs from the two in that it signals through a G protein-coupled receptor, LGR8. INSL3/LGR8 signaling is involved in gubernaculum development and transabdominal testicular descent during development. Abnormal INSL3 production or action by the fetal testis causes cryptorchidism, a developmental defect of the urogenital tract in human males wherein the testis do not descend into the scrotum during embryonic development. Infertility and the development of germ-cell tumors are two potential risks for individuals with cryptorchidism.

CAS Number

9007-83-4

Structure Composition

1mg/ml in PBS with 0.02% sodium azide, 50% glycerol, pH7.2

Product Name Alternative

INSL 3; INSL-3; INSL3_HUMAN; Insulin like 3; Insulin-like 3 A chain; Ley IL; Ley-I-L; Leydig insulin like peptide; Leydig insulin-like peptide; Relaxin like factor; Relaxin-like factor; RLF; RLNL

Swiss Prot

P51460

Reactivity

Human, Mouse, Rat

Immunogen

Recombinant fusion protein containing a sequence corresponding to amino acids 1-131 ofhuman INSL3 (NP_005534.2) .

Conjugation

Unconjugated

Applications

IHC-P IF/ICC ELISA

Dilution

IHC-P 1:50 - 1:100 IF/ICC 1:50 - 1:100 ELISA 1:5000 - 1:10000

Purity

The antibody was affinity-purified from rabbit antiserum by affinity-chromatography using epitope-specific immunogen and the purity is > 95% (by SDS-PAGE) .