CD305 polyclonal antibody
Product Specifications
Background
LAIR-1 is an inhibitory receptor that belongs to the Immunoglobulin superfamily. It has one extracellular Ig-like domain and an intracellular C-terminus with two ITIM (immunoreceptor tyrosine-based inhibitory motif) domains. It is found on peripheral mononuclear cells, including NK, T, and B cells, and is thought to play a negative regulatory role on the cytolytic function of these cells through signaling through collagen ligation. LAIR1 has been noted to be upregulated in renal cell carcinoma, and may play a role in expansion of Th17 cell populations in collagen-rich environments, such as in graft rejection tissue.
CAS Number
9007-83-4
Structure Composition
Rabbit IgG, 1mg/ml in PBS with 0.02% sodium azide, 50% glycerol, pH7.2.
Product Name Alternative
Leukocyte-associated immunoglobulin-like receptor 1; LAIR-1; hLAIR1; LAIR1
Swiss Prot
Q6GTX8
Reactivity
Human
Immunogen
Recombinant protein of human CD305.
Conjugation
Unconjugated
Applications
WB IF
Dilution
WB: 1:1000~1:2000 IF: 1:100~1:500
Purity
The antibody was affinity-purified from rabbit antiserum by affinity-chromatography using epitope-specific immunogen and the purity is > 95% (by SDS-PAGE) .
Modification
Unmodified
Molecular Weight
~ 46 kDa
Storage Conditions
Store at 4°C short term. Aliquot and store at -20°C long term. Avoid freeze-thaw cycles.
Notes
For research use only, not for use in diagnostic procedure.
Specificity
CD305 polyclonal antibody detects endogenous levels of CD305 protein.
Applications Notes
Western blot (WB) analysis of CD305 polyclonal antibody at 1:1000 dilution Lane1:THP-1 whole cell lysate (30ug Lane2:L02 cell membrane lysate (24ug) Lane3:MCF-7 cell membrane lysate (24ug)
Host or Source
Rabbit
Available Sizes
Frequently Asked Questions
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