Tuberin (F933) polyclonal antibody
Product Specifications
Background
Tuberin, or TSC2 (Tuberous sclerosis complex), is implicated as a tumor suppressor. It may function in vesicular transport, and may also play a role in the regulation of cell growth arrest and in the regulation of transcription mediated by steroid receptors. Interaction between hamartin (TSC1) and tuberin may facilitate vesicular docking. It specifically stimulates the intrinsic GTPase activity of the Ras related protein RAP1A and RAB5, suggesting a possible mechanism for its role in regulating cellular growth. Mutations in tuberin lead to constitutive activation of RAP1A in tumors. At least three isoforms of Tuberin exist.
CAS Number
9007-83-4
Structure Composition
Rabbit IgG, 1mg/ml in PBS with 0.02% sodium azide, 50% glycerol, pH7.2
Product Name Alternative
Tuberin; Tuberous sclerosis 2 protein; TSC2; TSC4
Swiss Prot
P49815
Reactivity
Human, Mouse, Rat
Immunogen
Synthetic peptide, corresponding to amino acids 900-950 of Human Tuberin.
Conjugation
Unconjugated
Related Pathways
Insulin &Glucose Signaling
Applications
WB IHC IF
Dilution
WB: 1:500~1:1000 IHC: 1:50~1:200 IF: 1:50~1:200
Purity
The antibody was affinity-purified from rabbit antiserum by affinity-chromatography using epitope-specific immunogen and the purity is > 95% (by SDS-PAGE) .
Modification
Unmodified
Molecular Weight
~ 200 kDa
Storage Conditions
Store at 4°C short term. Aliquot and store at -20°C long term. Avoid freeze-thaw cycles.
Notes
For research use only, not for use in diagnostic procedure.
Specificity
Tuberin/TSC2 (F933) polyclonal antibody detects endogenous levels of Tuberin/TSC2 protein.
Applications Notes
Western blot (WB) analysis of Tuberin (F933) polyclonal antibody at 1:500 dilution Lane1:C6 whole cell lysate (40ug) Lane2:MEF whole cell lysate (40ug) Lane3:A549 whole cell lysate (40ug) Lane4:L02 whole cell lysate (40ug)
Host or Source
Rabbit
Available Sizes
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