Phospho-CaMK2 alpha (Thr305) Polyclonal Antibody

Product Specifications

Background

Ca2+/CalmodulinDependent Protein Kinase II (CaM Kinase II) is a multifunctional calcium and calmodulindependent protein kinase that mediates cellular responses to a wide variety of intercellular signals. CaM Kinase II has been shown to regulate diverse cellular functions including synaptic plasticity, neurotransmitter synthesis and release, gene expression, ion channel function, carbohydrate metabolism, cytoskeletal function, and Ca2+homeostasis. Phosphorylation of Thr286 on the kinase produces an autonomously active form of CaM Kinase II. Autophosphorylation of Thr305 inhibits the activity CaM Kinase II. Phosphorylation at this site appears to reduce the association of CaM Kinase II with the PSD and reduce LTP and learning.

CAS Number

9007-83-4

Structure Composition

Rabbit IgG, 1mg/ml in PBS with 0.02% sodium azide, 50% glycerol, pH7.2

Product Name Alternative

CAMK2A; CAMKA; KIAA0968; Calcium/calmodulin-dependent protein kinase type II subunit alpha; CaM kinase II subunit alpha; CaMK-II subunit alpha; CAMK2B; CAM2; CAMK2; CAMKB; Calcium/calmodulin-dependent protein kinase type II subunit beta; CaM kinase II sub

Swiss Prot

Q13554

Reactivity

Human, Mouse, Rat

Immunogen

KLH-conjugated synthetic phosphopeptide corresponding to residues surrounding T305 of human CaMK2 alpha protein.

Conjugation

Unconjugated

Related Pathways

Phospholipase Signaling, Contribution of Soluble Factors to EMT, G Protein-coupled Receptors Signaling to MAPK Erk, ErbB HER Signaling

Applications

WB, IHC

Dilution

WB,1:500 - 1:1000|IHC,1:50 - 1:100

Purity

The antibody was affinity-purified from rabbit antiserum by affinity-chromatography using epitope-specific immunogen and the purity is > 95% (by SDS-PAGE) .