PERK (Phospho-Thr982) polyclonal antibody

Product Specifications

Background

The protein encoded by this gene phosphorylates the alpha subunit of eukaryotic translation-initiation factor 2 (EIF2), leading to its inactivation, and thus to a rapid reduction of translational initiation and repression of global protein synthesis. It is a type I membrane protein located in the endoplasmic reticulum (ER), where it is induced by ER stress caused by malfolded proteins. Mutations in this gene are associated with Wolcott-Rallison syndrome.

CAS Number

9007-83-4

Structure Composition

Rabbit IgG, 1mg/ml in PBS with 0.02% sodium azide, 50% glycerol, pH7.2

Product Name Alternative

P-PERK (Thr980) ; PERK (Phospho Thr980) ; PERK (Phospho T980) ; HRI; HsPEK; Pancreatic eIF2-alpha kinase; PEK; PRKR like endoplasmic reticulum kinase; WRS; DKFZp781H1925; EC 2.7.11.1; EIF2AK3; Eukaryotic translation initiation factor 2 alpha kinase 3; Heme regulated EIF2 alpha kinase

Swiss Prot

Q9NZJ5

Reactivity

Human, Mouse

Immunogen

KLH-conjugated synthetic peptide encompassing a sequence within the C-term region of human PERK.

Conjugation

Unconjugated

Related Pathways

Translational Contral Regulation of elF2

Applications

WB IHC

Dilution

WB 1:500 - 1:1000 IHC 1:100 - 1:200

Purity

The antibody was affinity-purified from rabbit antiserum by affinity-chromatography using epitope-specific immunogen and the purity is > 95% (by SDS-PAGE) .