NCF2 polyclonal antibody
Product Specifications
Background
NCF2, NCF1, and a membrane bound cytochrome b558 are required for activation of the latent NADPH oxidase (necessary for superoxide production) . Defects in NCF2 are a cause of chronic granulomatous disease autosomal recessive cytochrome-b-positive type 2 (CGD2) . Chronic granulomatous disease is a genetically heterogeneous disorder characterized by the inability of neutrophils and phagocytes to kill microbes that they have ingested. Patients suffer from life-threatening bacterial/fungal infections.
CAS Number
9007-83-4
Structure Composition
Rabbit IgG, 1mg/ml in PBS with 0.02% sodium azide, 50% glycerol, pH7.2
Product Name Alternative
67 a neutrophil oxidase factor; Chronic granulomatous disease autosomal 2; NADPH oxidase activator 2; NCF-2; Ncf2; NCF2; Neutrophil cytosol factor 2; Neutrophil NADPH oxidase factor 2; NOXA2; p67-phox; p67phox
Swiss Prot
P19878
Reactivity
Human, Mouse, Rat
Immunogen
Recombinant full length Human NCF2.
Conjugation
Unconjugated
Applications
WB IHC IF/ICC IP
Dilution
WB: 1:500~1:2000 IHC: 1:50~1:200 IF/ICC: 1:50~1:200 IP: 1:20~1:100
Purity
The antibody was affinity-purified from rabbit antiserum by affinity-chromatography using epitope-specific immunogen and the purity is > 95% (by SDS-PAGE) .
Modification
Unmodified
Molecular Weight
~ 68 kDa
Storage Conditions
Store at 4°C short term. Aliquot and store at -20°C long term. Avoid freeze-thaw cycles.
Notes
For research use only, not for use in diagnostic procedure.
Specificity
NCF2 polyclonal antibody detects endogenous levels of NCF2 protein.
Applications Notes
Western blot analysis of p67 phox expression in THP1 (A), mouse spleen (B) whole cell lysates.
Host or Source
Rabbit
Available Sizes
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