SSSCA1 mouse monoclonal antibody

Product Specifications

Background

SSSCA1 (sjogren syndrome/scleroderma autoantigen 1), also known as p27, is a 199 amino acid protein that may play a role in mitosis. Considered a centromere-associated protein, SSSCA1 may induce anti-centromere antibodies. SSSCA1 is phosphorylated upon DNA damage by ATM or ATR. The gene encoding SSSCA1 maps to human chromosome 11, which houses over 1,400 genes and comprises nearly 4% of the human genome. Jervell and Lange-Nielsen syndrome, Jacobsen syndrome, Niemann-Pick disease, hereditary angioedema and Smith-Lemli-Opitz syndrome are associated with defects in genes that maps to chromosome 11.

CAS Number

9007-83-4

Structure Composition

1mg/ml in PBS with 0.02% sodium azide, 50% glycerol, pH7.2

Product Name Alternative

Protein ZNRD2; Autoantigen p27; Sjoegren syndrome/scleroderma autoantigen 1; Zinc ribbon domain-containing protein 2; ZNRD2; SSSCA1

Swiss Prot

O60232

Reactivity

Human

Immunogen

Full length human recombinant protein of human SSSCA1 (NP_006387) produced in HEK293T cell.

Conjugation

Unconjugated

Applications

FC, IF, IHC, WB

Dilution

WB 1:2000, IF 1:100, FLOW 1:100, IHC: 1:150

Purity

The antibody was affinity-purified from mouse ascites fluids or tissue culture supernatant by affinity-chromatography using epitope-specific immunogen and the purity is > 95% (by SDS-PAGE) .