NKRF mouse monoclonal antibody

Product Specifications

Background

NF-κB Repressing Factor (NKRF) is a constitutively expressed transcription factor that binds to the negative regulatory element within the promotor region of many genes that are transactivated by NF-κB (1) . Indeed, research studies have found NKRF to repress transcription of IL-8/CXCL8, iNOS, CXCL10, and IFN-γ (2-4) . In addition to regulating the expression of pro-inflammatory factors, NKRF has been shown to play a role in cell survival in the context of proteotoxic stress, through the regulation of rRNA processing and ribosome biogenesis (5) .

CAS Number

9007-83-4

Structure Composition

1mg/ml in PBS with 0.02% sodium azide, 50% glycerol, pH7.2

Product Name Alternative

NF-kappa-B-repressing factor; NFkB-repressing factor; Protein ITBA4; NKRF; ITBA4, NRF; 9606 NCBIHomo sapiens (Human)

Swiss Prot

O15226

Reactivity

Human, Mouse

Immunogen

Human recombinant protein fragment corresponding to amino acids 1-296 of human NKRF (NP_060014) produced in E.coli.

Conjugation

Unconjugated

Applications

Dilution

WB 1:2000

Purity

The antibody was affinity-purified from mouse ascites fluids or tissue culture supernatant by affinity-chromatography using epitope-specific immunogen and the purity is > 95% (by SDS-PAGE) .