GEMIN2 mouse monoclonal antibody
Product Specifications
Background
This gene encodes one of the proteins found in the SMN complex, which consists of several gemin proteins and the protein known as the survival of motor neuron protein. The SMN complex is localized to a subnuclear compartment called gems (gemini of coiled bodies) and is required for assembly of spliceosomal snRNPs and for pre-mRNA splicing. This protein interacts directly with the survival of motor neuron protein and it is required for formation of the SMN complex. A knockout mouse targeting the mouse homolog of this gene exhibited disrupted snRNP assembly and motor neuron degeneration.
CAS Number
9007-83-4
Structure Composition
1mg/ml in PBS with 0.02% sodium azide, 50% glycerol, pH7.2
Product Name Alternative
SIP1; SIP1-delta; gem nuclear organelle associated protein 2
Swiss Prot
O14893
Reactivity
Human, Mouse, Rat
Immunogen
Full length human recombinant protein of human GEMIN2 (NP_003607) produced in E.coli.
Conjugation
Unconjugated
Applications
IHC, WB
Dilution
WB 1:2000, IHC 1:150
Purity
The antibody was affinity-purified from mouse ascites fluids or tissue culture supernatant by affinity-chromatography using epitope-specific immunogen and the purity is > 95% (by SDS-PAGE) .
Modification
Unmodified
Molecular Weight
~ 33 kDa
Storage Conditions
Store at 4°C short term. Aliquot and store at -20°C long term. Avoid freeze-thaw cycles.
Notes
For research use only, not for use in diagnostic procedure.
Specificity
IgG1
Applications Notes
Western blot (WB) analysis of GEMIN2 mouse monoclonal antibody at 1:500 dilution Lane1:HepG2 whole cell lysate (30ug) Lane2:HEK293T whole cell lysate (30ug)
Host or Source
Mouse
Available Sizes
Curated Selection
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