IFIT3 mouse monoclonal antibody

IFIT3 (Interferon-induced protein with tetratricopeptide repeats 3; Retinoic acid-induced gene G protein (RIG-G) ) is part of the IFIT family of interferon-stimulating genes known for their antiviral properties (1,2) . IFIT3 is widely expressed in T cells, B cells, plasmacytoid and myeloid dendritic cells, neurons, and kidney cells (3,4) . In response to RNA viral infection, IFIT3 regulates IRF3 activation through interaction with TBK1 and MAVS on the mitochondrion (5) . IFIT3 also interacts with IFIT1, leading to inhibitory activity against viral RNA lacking the 2′-O-methylation in the cap structure (6) .

Gem-associated protein 2; Gemin-2; Component of gems 2; Survival of motor neuron protein-interacting protein 1 (SMN-interacting protein 1) ; GEMIN2; SIP1

The antibody was affinity-purified from mouse ascites fluids or tissue culture supernatant by affinity-chromatography using epitope-specific immunogen and the purity is > 95% (by SDS-PAGE) .

Western blot (WB) analysis of IFIT3 mouse monoclonal antibody at 1:500 dilution Lane1:HepG2 whole cell lysate (30ug); Lane2:The Lung tissue lysate of mouse (30ug); Lane3:The Liver tissue lysate of Rat (30ug)