O-Phenanthroline

O-Phenanthroline (1,10-Phenanthroline), a metal chelator, prevents the induction of chromosomal aberrations in streptozotocin-treated cells. o-Phenanthroline (1,10-Phenanthroline) forms a red chelate with Fe2+ that absorbs maximally at 510 nm. o-Phenanthroline (1,10-Phenanthroline) is also a MMP inhibitor[1][2].

Product Specifications

CAS Number

[66-71-7]

Product Name Alternative

1,10-Phenanthroline

UNSPSC

12352200

Hazard Statement

H301, H410

Target

MMP

Type

Biochemical Assay Reagents

Related Pathways

Metabolic Enzyme/Protease

Field of Research

Others

Assay Protocol

https://www.medchemexpress.com/o-phenanthroline.html

Purity

99.99

Solubility

DMSO : 100 mg/mL (ultrasonic) |Ethanol : 50 mg/mL (ultrasonic) |H2O : 2 mg/mL (ultrasonic)

Smiles

C12=C(N=CC=C3)C3=CC=C1C=CC=N2

Molecular Formula

C12H8N2

Molecular Weight

180.21

Precautions

H301, H410

References & Citations

[1]Guan NanMu, et al. Synergistic inhibition between o-phenanthroline and chloride ion on cold rolled steel corrosion in phosphoric acid. Materials Chemistry and Physics Volume 86, Issue 1, 15 July 2004, Pages 59-68.|[2]Zi-Qiang Liu, et al. The role of matrix metalloprotease (MMP) to the autolysis of sea cucumber (Stichopus japonicus) . J Sci Food Agric. 2019 Oct;99 (13) :5752-5759.

Shipping Conditions

Room Temperature

Storage Conditions

RT, protect from light, stored under nitrogen

Scientific Category

Biochemical Assay Reagents

Clinical Information

No Development Reported

Citation 01

Adv Sci (Weinh) . 2025 Aug 30:e09817.|Ind Crops Prod. 2024 Sep 1, 215, 118652.|Mol Cell. 2023 Nov 16;83 (22) :4000-4016.e6.|Nat Commun. 2023 May 2;14 (1) :2523.