Carbazomycin B
Carbazomycin B is a bacterial metabolite and can be isolated from Streptomyces. Carbazomycin B is an antifungal and antibacterial agent. Carbazomycin B inhibits 5-lipoxygenase (5-LO) activity in extract from RBL-1 cell with the IC50 Of 1.5 µM[1]sup>[2]sup>[3]sup>[4].
Product Specifications
CAS Number
75139-38-7
UNSPSC
12352005
Target
Antibiotic; Bacterial; Lipoxygenase
Type
Natural Products
Related Pathways
Anti-infection; Metabolic Enzyme/Protease
Applications
COVID-19-immunoregulation
Field of Research
Cancer; Infection
Assay Protocol
https://www.medchemexpress.com/carbazomycin-b.html
Smiles
OC1=C(C(C)=C(C)C2=C1C3=C(C=CC=C3)N2)OC
Molecular Formula
C15H15NO2
Molecular Weight
241.29
References & Citations
[1]Sakano K, et al. New antibiotics, carbazomycins A and B. I. Fermentation, extraction, purification and physico-chemical and biological properties. J Antibiot (Tokyo) . 1980;33 (7) :683-689. |[2]Naid T, et al. Carbazomycins C, D, E and F, minor components of the carbazomycin complex. J Antibiot (Tokyo) . 1987;40 (2) :157-164. |[3]Hook DJ, et al. Identification of the inhibitory activity of carbazomycins B and C against 5-lipoxygenase, a new activity for these compounds. J Antibiot (Tokyo) . 1990 Oct;43 (10) :1347-8. |[4]Yamasaki K, Kaneda M, Watanabe K, et al. New antibiotics, carbazomycins A and B. III. Taxonomy and biosynthesis. J Antibiot (Tokyo) . 1983;36 (5) :552-558.
Shipping Conditions
Room temperature
Scientific Category
Natural Products
Clinical Information
No Development Reported
Available Sizes
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