BCATc Inhibitor 2

BCATc Inhibitor 2 is a selective branched-chain aminotransferase (BCAT) inhibitor for research of neurodegenerative diseases. The IC50s of 0.2 μM, 0.8 μM and 3.0 μM for rat cytosolic isoenzyme rBCATc, human cytosolic isoenzyme hBCATc and rat mitochondrial isoenzyme rBCATm, respectively. BCATc, also called BCAT1, is in the cytoplasm[1].

Product Specifications

CAS Number

[406191-34-2]

Product Name Alternative

(+)-MCPG

UNSPSC

12352005

Hazard Statement

H315, H319

Target

Aminotransferases (Transaminases)

Type

Reference compound

Related Pathways

Metabolic Enzyme/Protease

Applications

Neuroscience-Neurodegeneration

Field of Research

Neurological Disease

Assay Protocol

https://www.medchemexpress.com/bcatc-inhibitor-2.html

Concentration

10mM

Purity

99.28

Solubility

DMSO : 250 mg/mL (ultrasonic)

Smiles

ClC1=CC=C2C(C=C(O2)C(NNS(C3=C(C=CC=C3)C(F)(F)F)(=O)=O)=O)=C1

Molecular Formula

C16H10ClF3N2O4S

Molecular Weight

418.77

Precautions

H315, H319

References & Citations

[1]Lain-Yen Hu, et al. The Design and Synthesis of Human Branched-Chain Amino Acid Aminotransferase Inhibitors for Treatment of Neurodegenerative Diseases. Bioorg Med Chem Lett. 2006 May 1;16 (9) :2337-40.