CP-481715

CP-481715 is a potent, reversible and selective CCR1 antagonist with a Kd of 9.2 nM for human CCR1. CP-481715 is >100-fold selective for CCR1 as compared with a panel of G-protein-coupled receptors including related chemokine receptors. CP-481715 has the potential for rheumatoid arthritis and other inflammatory diseases research[1].

Product Specifications

CAS Number

[212790-31-3]

UNSPSC

12352005

Hazard Statement

H302-H315-H319-H335

Target

CCR

Type

Reference compound

Related Pathways

GPCR/G Protein; Immunology/Inflammation

Applications

COVID-19-immunoregulation

Field of Research

Inflammation/Immunology

Assay Protocol

https://www.medchemexpress.com/cp-481715.html

Smiles

O=C(C1=NC2=CC=CC=C2N=C1)N[C@@H](CC3=CC=CC(F)=C3)[C@@H](O)C[C@H](C(N)=O)CCC(C)(O)C

Molecular Formula

C26H31FN4O4

Molecular Weight

482.55

Precautions

P261-P280-P302+P352

References & Citations

[1]Gladue RP, Tylaska LA, Brissette WH, Lira PD, Kath JC, Poss CS, Brown MF, Paradis TJ, Conklyn MJ, Ogborne KT, McGlynn MA, Lillie BM, DiRico AP, Mairs EN, McElroy EB, Martin WH, Stock IA, Shepard RM, Showell HJ, Neote K.CP-481,715, a potent and selective CCR1 antagonist with potential therapeutic implications for inflammatory diseases.J Biol Chem. 2003 Oct 17;278 (42) :40473-80. Epub 2003 Aug 7.|[2]Borregaard J, Skov L, Wang L, Ting N, Wang C, Beck LA, Sonne J, Clucas A.Evaluation of the effect of the specific CCR1 antagonist CP-481715 on the clinical and cellular responses observed following epicutaneous nickel challenge in human subjects.Contact Dermatitis. 2008 Oct;59 (4) :212-9.|[3]Gladue RP, Cole SH, Roach ML, Tylaska LA, Nelson RT, Shepard RM, McNeish JD, Ogborne KT, Neote KS.The human specific CCR1 antagonist CP-481,715 inhibits cell infiltration and inflammatory responses in human CCR1 transgenic mice.J Immunol. 2006 Mar 1;176 (5) :3141-8.|[4]Ronald P Gladue, et al. CP-481,715, a potent and selective CCR1 antagonist with potential therapeutic implications for inflammatory diseases. J Biol Chem. 2003 Oct 17;278 (42) :40473-80.