Hck Protein, Active

<strong>Hck Protein, Active</strong>_x000D_ <strong>Catalog number:</strong> B2019391_x000D_ <strong>Lot number:</strong> Batch Dependent_x000D_ <strong>Expiration Date:</strong> Batch dependent_x000D_ <strong>Amount:</strong> 5  µg_x000D_ <strong>Molecular Weight or Concentration:</strong> 34.1 kDa_x000D_ <strong>Supplied as:</strong> Resin_x000D_ <strong>Applications:</strong> a molecular tool for various biochemical applications_x000D_ <strong>Storage:</strong> −70°C_x000D_ <strong>Keywords:</strong> Hck Protein, Active_x000D_ <strong>Grade:</strong> Biotechnology grade. All products are highly pure. All solutions are made with Type I ultrapure water (resistivity &gt;18 MΩ-cm) and are filtered through 0.22 um._x000D_ _x000D_ <strong>References:</strong>_x000D_ 1: Futosi K, Fodor S, Mócsai A. Neutrophil cell surface receptors and their intracellular signal transduction pathways Int Immunopharmacol. 2013 Nov;17(3):638-50._x000D_ 2: Chen M, Menon MC, Wang W, Fu J, Yi Z, Sun Z, Liu J, Li Z, Mou L, Banu K, Lee SW, Dai Y, Anandakrishnan N, Azeloglu EU, Lee K, Zhang W, Das B, He JC, Wei C. HCK induces macrophage activation to promote renal inflammation and fibrosis via suppression of autophagy Nat Commun. 2023 Jul 18;14(1):4297._x000D_ 3: Zheng X, Song J, Yu C, Zhou Z, Liu X, Yu J, Xu G, Yang J, He X, Bai X, Luo Y, Bao Y, Li H, Yang L, Xu M, Song N, Su X, Xu J, Ma X, Shi H. Single-cell transcriptomic profiling unravels the adenoma-initiation role of protein tyrosine kinases during colorectal tumorigenesis Signal Transduct Target Ther. 2022 Feb 28;7(1):60._x000D_ 4: Musumeci F, Schenone S, Brullo C, Desogus A, Botta L, Tintori C. Hck inhibitors as potential therapeutic agents in cancer and HIV infection Curr Med Chem. 2015;22(13):1540-64._x000D_ 5: Lantermans HC, Ma F, Kuil A, van Kesteren S, Yasinoglu S, Yang G, Buhrlage SJ, Wang J, Gray NS, Kersten MJ, Treon SP, Pals ST, Spaargaren M. The dual HCK/BTK inhibitor KIN-8194 impairs growth and integrin-mediated adhesion of BTKi-resistant mantle cell lymphoma Leukemia. 2024 Jul;38(7):1570-1580._x000D_ 6: Poh AR, O'Donoghue RJ, Ernst M. Hematopoietic cell kinase (HCK) as a therapeutic target in immune and cancer cells Oncotarget. 2015 Jun 30;6(18):15752-71._x000D_ 7: Yang G, Wang J, Tan L, Munshi M, Liu X, Kofides A, Chen JG, Tsakmaklis N, Demos MG, Guerrera ML, Xu L, Hunter ZR, Che J, Patterson CJ, Meid K, Castillo JJ, Munshi NC, Anderson KC, Cameron M, Buhrlage SJ, Gray NS, Treon SP. The HCK/BTK inhibitor KIN-8194 is active in MYD88-driven lymphomas and overcomes mutated BTKCys481 ibrutinib resistance Blood. 2021 Nov 18;138(20):1966-1979._x000D_ 8: Sakoda T, Kikushige Y, Miyamoto T, Irifune H, Harada T, Hatakeyama K, Kunisaki Y, Kato K, Akashi K. TIM-3 signaling hijacks the canonical Wnt/β-catenin pathway to maintain cancer stemness in acute myeloid leukemia Blood Adv. 2023 May 23;7(10):2053-2065._x000D_ 9: Ochieng P, Nath S, Macarulay R, Eden E, Dabo A, Campos M, Jiang XC, Foronjy RF, Geraghty P. Phospholipid transfer protein and alpha-1 antitrypsin regulate Hck kinase activity during neutrophil degranulation Sci Rep. 2018 Oct 18;8(1):15394._x000D_ <a href="https://pubmed.ncbi.nlm.nih.gov/12029088">10: Scott MP, Zappacosta F, Kim EY, Annan RS, Miller WT. Identification of novel SH3 domain ligands for the Src family kinase Hck. Wiskott-Aldrich syndrome protein (WASP), WASP-interacting protein (WIP), and ELMO1 J Biol Chem. 2002 Aug 2;277(31):28238-46. </a>_x000D_ _x000D_ <strong>Products Related to Hck Protein, Active can be found at</strong> <a href="https://moleculardepot.com/product-category/Proteins/"> Proteins</a>