PW0729

PW0729 (compound 15b) is an orphan GPR52 agonist with potential applications in GPR52 activation, signaling bias, and neuropsychiatric and neurological disorders. The brain exposure characteristics of PW0729 need to be further optimized[1].

Product Specifications

CAS Number

[2767348-36-5]

UNSPSC

12352005

Target

GPR52

Type

Reference compound

Related Pathways

GPCR/G Protein

Field of Research

Neurological Disease

Assay Protocol

https://www.medchemexpress.com/pw0729.html

Smiles

O=C(C1=CC=CC(NC2=CC(CC3=CC=CC(C(F)(F)F)=C3)=CC=N2)=C1C)NCCO

Molecular Formula

C23H22F3N3O2

Molecular Weight

429.43

References & Citations

[1]Murphy R E, Wang P, Ali S, et al. Discovery of 3- ((4-Benzylpyridin-2-yl) amino) benzamides as Potent GPR52 G Protein-Biased Agonists[J]. Journal of Medicinal Chemistry, 2024.