A-70874
A-70874 is a tyrosine-free tetrapeptide analog of cholecystokinin (30-33) (CCK-4) . A-70874 is an agonist that stimulates pancreatic amylase release and a partial agonist that stimulates pancreatic phosphoinositide decomposition. A-70874 has an IC50 of 4.9 nM for the guinea pig pancreatic CCK receptor. Cholecystokinin (CCK) receptors are divided into CCK-A (digestive tract) and CCK-B (brain) . A-70874 has an affinity of 1.6 μM for the CCK-B/gastrin receptor[1].
Product Specifications
CAS Number
131449-37-1
UNSPSC
12352005
Target
Cholecystokinin Receptor
Type
Reference compound
Related Pathways
GPCR/G Protein; Neuronal Signaling
Field of Research
Metabolic Disease
Assay Protocol
https://www.medchemexpress.com/a-70874.html
Smiles
NC([C@H](CC1=CC=CC=C1)N(C)C([C@H](CC(O)=O)NC([C@H](CCCCNC(/C=C/C2=CC=C(O)C=C2)=O)NC([C@@H](NC(OC(C)(C)C)=O)CC3=CNC4=C3C=CC=C4)=O)=O)=O)=O
Molecular Formula
C45H55N7O10
Molecular Weight
853.96
References & Citations
Shipping Conditions
Room temperature
Scientific Category
Reference compound1
Clinical Information
No Development Reported
Frequently Asked Questions
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