C450-0730

C450-0730 is an antagonist targeting the AHL membrane-bound sensor kinase and is an antagonist of the nine-transmembrane protein LuxN of Vibrio harveyi . C450-0730 competitively binds to the LuxN AI-1 binding site and specifically antagonizes the LuxN/AI-1 quorum sensing signal in Vibrio harveyi. The inhibitory activity of C450-0730 against LuxNI209F was not significant[1].

Product Specifications

CAS Number

[1036730-46-7]

UNSPSC

12352005

Hazard Statement

H302-H315-H319-H335

Target

Bacterial

Type

Reference compound

Related Pathways

Anti-infection

Applications

COVID-19-immunoregulation

Field of Research

Infection

Assay Protocol

https://www.medchemexpress.com/c450-0730.html

Purity

97.0

Smiles

CC(C)CC(NS(=O)(C1=CC2=C(N(C(C)=O)CC2)C=C1)=O)C(NCC3=CC=C(Cl)C=C3)=O

Molecular Formula

C23H28ClN3O4S

Molecular Weight

478.00

Precautions

P261-P264-P270-P271-P280-P302+P352-P304+P340-P305+P351+P338-P330-P362+P364-P403+P233-P405-P501

References & Citations

[1]Swem LR, et al. Deducing receptor signaling parameters from in vivo analysis: LuxN/AI-1 quorum sensing in Vibrio harveyi. Cell. 2008 Aug 8;134 (3) :461-73.