MS934
MS934 is a novel improved VHL-recruiting MEK 1/2 PROTAC degrader. MS934 also degrades CRAF. MS934 can be used for the research of variety of human cancers, such as melanoma, nonsmall cell lung cancer (NSCLC), colorectal cancer, primary brain tumors, and hepatocellular carcinoma (Pink: Target protein ligand ; Black: linker (HY-168289) ; Blue: E3 ligase ligand (HY-112078) )[2][3].
Product Specifications
CAS Number
2756323-15-4
UNSPSC
12352005
Target
MEK; PROTACs; Raf
Type
Reference compound
Related Pathways
MAPK/ERK Pathway; PROTAC
Applications
Cancer-Kinase/protease
Field of Research
Cancer
Assay Protocol
https://www.medchemexpress.com/ms934.html
Purity
98.48
Solubility
DMSO : ≥ 50 mg/mL
Smiles
O=C(C1=C(C(F)=C(C=C1)F)NC2=C(C=C(C=C2)I)F)NOCCCCNCCCCCCCCCCCC(N[C@@H](C(C)(C)C)C(N3[C@@H](C[C@H](C3)O)C(N[C@H](C4=CC=C(C5=C(N=CS5)C)C=C4)C)=O)=O)=O
Molecular Formula
C52H69F3IN7O6S
Molecular Weight
1104.11
References & Citations
Shipping Conditions
Blue Ice
Storage Conditions
-20°C (Powder, protect from light, stored under nitrogen)
Scientific Category
Reference compound1
Clinical Information
No Development Reported
Isoform
C-Raf
Available Sizes
Frequently Asked Questions
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