Stachydrine (hydrochloride)

Stachydrine hydrochloride is the major active constituent of Leonurus artemisia, which is a potential therapy for cardiovascular diseases[2]. Stachydrine can inhibit the NF-κB signal pathway. Anti-hypertrophic activities[1].

Product Specifications

CAS Number

[4136-37-2]

UNSPSC

12352005

Hazard Statement

H302, H315, H319, H335

Target

Endogenous Metabolite; NF-κB

Type

Natural Products

Related Pathways

Metabolic Enzyme/Protease; NF-κB

Applications

COVID-19-immunoregulation

Field of Research

Cardiovascular Disease; Cancer

Assay Protocol

https://www.medchemexpress.com/Stachydrine_hydrochloride.html

Purity

98.0

Solubility

DMSO : 100 mg/mL (ultrasonic) |H2O : 100 mg/mL (ultrasonic)

Smiles

C[N+]1(CCC[C@H]1C([O-])=O)C.Cl

Molecular Formula

C7H14ClNO2

Molecular Weight

179.64

Precautions

H302, H315, H319, H335

References & Citations

[1]Guo W, et al. Effect of Leonurus Stachydrine on myocardial cell hypertrophy. Zhong Yao Cai. 2012 Jun;35 (6) :940-3.|[2]Wang M, et al. Stachydrine hydrochloride inhibits proliferation and induces apoptosis of breast cancer cells via inhibition of Akt and ERK pathways. Am J Transl Res. 2017 Apr 15;9 (4) :1834-1844.