Rhoifolin
Rhoifolin is a flavone glycoside can be isolated from Rhus succedanea. Rhoifolin has anti-diabetic effect acting through enhanced adiponectin secretion, tyrosine phosphorylation of insulin receptor-β and glucose transporter 4 (GLUT 4) translocation. Rhoifolin has an anti-inflammatory action via multi-level regulation of inflammatory mediators. Rhoifolin ameliorates titanium particle-stimulated osteolysis and attenuates osteoclastogenesis via RANKL-induced NF-κB and MAPK pathways. Rhoifolin also has cytotoxic activity against different cancer cell lines[1][2][3].
Product Specifications
CAS Number
[17306-46-6]
UNSPSC
12352005
Hazard Statement
H302, H315, H319, H335
Target
Autophagy; GLUT; Insulin Receptor; NF-κB; p38 MAPK
Type
Natural Products
Related Pathways
Autophagy; MAPK/ERK Pathway; Membrane Transporter/Ion Channel; NF-κB; Protein Tyrosine Kinase/RTK
Applications
Cancer-Kinase/protease
Field of Research
Metabolic Disease; Endocrinology; Cancer
Assay Protocol
https://www.medchemexpress.com/rhoifolin.html
Purity
99.25
Solubility
DMSO : 62.5 mg/mL (ultrasonic)
Smiles
O=C(C=C(C1=CC=C(O)C=C1)OC2=CC(O[C@H](O[C@H](CO)[C@@H](O)[C@@H]3O)[C@@H]3O[C@@](O[C@@H](C)[C@H](O)[C@H]4O)([H])[C@@H]4O)=C5)C2=C5O
Molecular Formula
C27H30O14
Molecular Weight
578.52
Precautions
H302, H315, H319, H335
References & Citations
Citrus grandis
Shipping Conditions
Room Temperature
Storage Conditions
4°C (Powder, protect from light, stored under nitrogen)
Scientific Category
Natural Products
Clinical Information
No Development Reported
Isoform
GLUT4; NF-κB
Available Sizes
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