Cariprazine (hydrochloride)

Cariprazine hydrochloride is a novel antipsychotic agent candidate that exhibits high affinity for the D3 (Ki=0.085 nM) and D2 (Ki=0.49 nM) receptors, and moderate affinity for the 5-HT1A receptor (Ki=2.6 nM) .

Product Specifications

CAS Number

[1083076-69-0]

Product Name Alternative

RGH188 hydrochloride

UNSPSC

12352005

Hazard Statement

H315, H319, H335

Target

5-HT Receptor; Dopamine Receptor

Type

Reference compound

Related Pathways

GPCR/G Protein; Neuronal Signaling

Applications

Neuroscience-Neuromodulation

Field of Research

Neurological Disease

Assay Protocol

https://www.medchemexpress.com/Cariprazine-hydrochloride.html

Purity

99.88

Solubility

DMSO : 6.67 mg/mL (ultrasonic) |H2O : 2.86 mg/mL (ultrasonic; warming; heat to 60°C)

Smiles

O=C(N[C@H]1CC[C@H](CCN2CCN(C3=CC=CC(Cl)=C3Cl)CC2)CC1)N(C)C.[H]Cl

Molecular Formula

C21H33Cl3N4O

Molecular Weight

463.87

Precautions

H315, H319, H335

References & Citations

[1]Seneca N, et al. Occupancy of dopamine D2 and D3 and serotonin 5-HT1A receptors by the novel antipsychotic drug candidate, cariprazine (RGH-188), in monkey brain measured using positron emission tomography. Psychopharmacology (Berl) . 2011 Dec;218 (3) :579-8|[2]Kiss B, et al. Cariprazine (RGH-188), a dopamine D (3) receptor-preferring, D (3) /D (2) dopamine receptor antagonist-partial agonist antipsychotic candidate: in vitro and neurochemical profile. J Pharmacol Exp Ther. 2010 Apr;333 (1) :328-40.|[3]Zimnisky R, et al. Cariprazine, a dopamine D (3) -receptor-preferring partial agonist, blocks phencyclidine-induced impairments of working memory, attention set-shifting, and recognition memory in the mouse. Psychopharmacology (Berl) . 2013 Mar;226 (1) :91-100.|[4]Gao Y, et al. Cariprazine exerts antimanic properties and interferes with dopamine D2 receptor β-arrestin interactions. Pharmacol Res Perspect. 2015 Feb;3 (1) :e00073.|[5]Citrome L. Cariprazine in schizophrenia: clinical efficacy, tolerability, and place in therapy. Adv Ther. 2013 Feb;30 (2) :114-26.