GR 89696

GR 89696 is a highly selective κ2 opioid receptor agonist with potential to prevent pruritus[1].

Product Specifications

CAS Number

[126766-32-3]

UNSPSC

12352005

Target

Opioid Receptor

Type

Reference compound

Related Pathways

GPCR/G Protein; Neuronal Signaling

Applications

COVID-19-immunoregulation

Field of Research

Inflammation/Immunology

Assay Protocol

https://www.medchemexpress.com/gr-89696.html

Concentration

10mM

Purity

99.88

Solubility

DMSO : ≥ 50 mg/mL

Smiles

OC(/C=C/C(O)=O)=O.ClC(C=C1CC(N2C(CN(CC2)C(OC)=O)CN3CCCC3)=O)=C(C=C1)Cl

Molecular Formula

C23H29Cl2N3O7

Molecular Weight

530.40

References & Citations

[1]Mei-Chuan Ko, et al. Effects of atypical kappa-opioid receptor agonists on intrathecal morphine-induced itch and analgesia in primates. J Pharmacol Exp Ther. 2009 Jan;328 (1) :193-200. |[2]A Barber, et al. Effects of GR-89696 and the novel peripherally selective OP2 agonists, EMD-61569 and EMD-61747, against focal cerebral ischemia in the rat. Methods Find Exp Clin Pharmacol. 1999 Mar;21 (2) :105-13